Small RNA repertoires and their intraspecies variation in Aggregatibacter actinomycetemcomitans
نویسندگان
چکیده
منابع مشابه
Proteomics of Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles
Aggregatibacter actinomycetemcomitans is an oral and systemic pathogen associated with aggressive forms of periodontitis and with endocarditis. Outer membrane vesicles (OMVs) released by this species have been demonstrated to deliver effector proteins such as cytolethal distending toxin (CDT) and leukotoxin (LtxA) into human host cells and to act as triggers of innate immunity upon carriage of ...
متن کاملIntraspecies variation in transfer RNA methyltransferases of inbred mice.
Intraspecies differences in transfer RNA (tRNA) methyltransferases have been investigated by comparing the activities of the liver tRNA-methylating enzymes of two inbred strains of mice. Since the tRNA methyltransferases are known to exhibit altered activities during carcinogenesis, it seemed of interest to compare the characteristics of these enzymes from inbred mice with either high (AKR/J) o...
متن کاملVirulence Mechanisms of Leukotoxin from Aggregatibacter actinomycetemcomitans
Aggregatibacter actinomycetemcomitans is a gram-negative bacterium that is present in the oral cavity of a large proportion of the human population (Zambon et al., 1983; Henderson et al., 2010) The bacterium is acquired through transmission from infected individuals and thought to initially colonize oral mucosa as a facultative intracellular pathogen (Fine et al., 2006). When the bacteria trans...
متن کاملProteomics of Protein Secretion by Aggregatibacter actinomycetemcomitans
The extracellular proteome (secretome) of periodontitis-associated bacteria may constitute a major link between periodontitis and systemic diseases. To obtain an overview of the virulence potential of Aggregatibacter actinomycetemcomitans, an oral and systemic human pathogen implicated in aggressive periodontitis, we used a combined LC-MS/MS and bioinformatics approach to characterize the secre...
متن کاملLeukotoxicity of Aggregatibacter actinomycetemcomitans in generalized aggressive periodontitis in Brazilians and their family members
OBJECTIVE The purpose of this study was to examine the leukotoxin promoter types of Aggregatibacter actinomycetemcomitans clones in subjects with generalized aggressive periodontitis (GAgP) and in their family members (FM). MATERIAL AND METHODS Thirty-five patients with GAgP (33.9±7.1 years), 33 of their FM (22.8±11.4 years), and 41 patients with chronic periodontitis (CP) (44.1±9.4 years) we...
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ژورنال
عنوان ژورنال: DNA Research
سال: 2017
ISSN: 1340-2838,1756-1663
DOI: 10.1093/dnares/dsx050